"How come" is a phrase that is commonly used to ask about the reason for something. However, there are several alternative synonyms that people can use to ask the same question. For example, people can use the phrase "why is that" or "what caused that." Other variations of this question can include "what's the deal" or "what's up with that." Additionally, people can use more formal versions such as "what is the reason behind that" or "what explains that." Overall, there are various ways to ask for an explanation, and people can choose the one that is most comfortable and appropriate for their situation.