How goes it is an informal way to ask about someone's well-being. There are several synonyms that can be used to convey the same meaning. Some of the common ones are "How are you doing?", "How's everything?", "What's up?" or "How's life treating you?". These expressions are a great way to initiate conversation and show someone that you care about their well-being. While there are variations in the way people greet each other depending on where they're from, the most important thing is to be genuine in your interest and concern for the other person's welfare.