"What's up" is a common phrase used to greet someone or inquire about their current situation or mood. However, there are several other synonyms that can be used in its place. Some common alternatives include "how's it going," "what's new," "what's happening," "how are you doing," and "what's going on." These phrases offer a similar sentiment and can be easily interchanged depending on the conversation and personal preference. It's important to remember that while the words used may differ, the intent remains the same - to initiate conversation and show interest in someone's current state.