The English language is rich in vocabulary and has a vast diversity of words that mean "in a new or different manner." Some synonyms for this phrase include "afresh," "differently," "distinctly," "uniquely," "unprecedentedly," "originally," "novelly," and "creatively." Using a synonym, depending on the context, can add variety and clarity to your writing or speech. For instance, instead of repeating the phrase, "In a new or different manner," you can use a synonym to enhance your message's tone, style and meaning. The appropriate synonym can help you convey your thoughts and ideas succinctly and effectively, leaving a lasting impression on your audience.