The word "in sanest" refers to the opposite of sanity, which is madness or insanity. Some antonyms for "in sanest" could be words like "sanest," "sane," or "composed." These words imply a sense of rationality, stability, and mental health, which are essential for leading a healthy and happy life. Other possible antonyms might include terms like "balanced," "normal," or "sensible." Whatever the case, the antonyms for "in sanest" are all positive words that suggest a state of mental well-being, emotional stability, and sound judgment. By avoiding the opposite of sanity, we can strive to lead productive and fulfilling lives.