The phrase "out of one's wit" is usually used to mean that someone is acting in a foolish or crazy manner. Some synonyms for this phrase include "out of one's mind," "insane," "mad," "crazy," "deranged," or "lunatic." These words all suggest a loss of control over one's thoughts or actions, and they are often associated with mental illness or intense emotional stress. In some cases, these terms may be used more colloquially to describe someone who is simply behaving in an unusual or erratic way. Whatever the context, words that suggest a lack of mental stability should always be used with caution and sensitivity.