The word "in-significance" implies worthlessness, triviality, or unimportance. The antonyms for in-significance are words like significance, importance, value, and relevance. A person or thing that is significant is significant because they or it has meaning, relevance, or purpose, and can impact or contribute positively to something. When we say that something is unimportant or insignificant, we undermine its value, and we reduce its worth or relevance. Therefore, adopting and using words that show the opposite of "in-significance," will help us express the importance and value that everything and everyone deserves.