The word "in-significancy" means lack of importance or relevance. Its antonyms, or words with opposite meanings, include significance, relevance, importance, meaning, and value. Significance refers to the quality of being important or having meaning, while relevance pertains to the quality of being related or applicable to a particular matter. Importance refers to the state or quality of being significant or having great value, and meaning refers to the significance or sense of something. Value pertains to the worth or usefulness of something. Thus, the antonyms of "in-significancy" reflect qualities that are crucial in determining the worth or value of something.