Infestive is a rather uncommon and infrequently used word, which means to be full of trouble. However, there are several synonyms that can be used interchangeably with infestive. Some of the most commonly used synonyms for infestive include vexatious, troublesome, irksome, annoying, and aggravating. Other words that can be used to describe something or someone that is infestive include pestilential, bothersome, nettlesome, and exasperating. These synonyms for infestive can be used in a variety of contexts, from describing a difficult task to remarking on the behavior of a person or group that causes distress.