Plaguy is a word that is used to describe something that is annoying or troublesome. There are several synonyms that can be used instead of plaguy, including vexatious, irksome, bothersome, and nettlesome. These synonyms can be used to describe a variety of situations, from a nagging headache to a difficult coworker. Other words that can be used instead of plaguy include bothersome, pesky, and troublesome. Each of these words has its own unique connotations, so it is important to choose the right one depending on the situation. No matter which synonym you choose, it is important to use it appropriately and accurately.