The word "plaguesome" is often used to describe something that is annoying or troublesome. There are several synonyms for this word that can be used to express the same meaning. Some of these synonyms include vexing, irritating, bothersome, pestering, harassing, and irksome. Each of these words is often used to describe a person or thing that is causing discomfort or frustration. For example, a loud and obnoxious neighbor can be described as vexing or irritating, while a persistent salesperson can be seen as pestering or harassing. Overall, there are many words that can be used to effectively convey the meaning of "plaguesome" in different contexts.