Innervating is defined as having a stimulating or energizing effect on someone or something. Therefore, its antonyms refer to words that have the opposite effect. Some antonyms for innervating include depressing, discouraging, disheartening, de-energizing, and demotivating. These words describe a feeling of low energy or a lack of stimulation. Other antonyms for innervating are sedating, calming, and soothing. These words describe a feeling of relaxation or a decrease in energy levels. Knowing the antonyms for innervating is useful when trying to communicate the opposite effect or mood of a particular word or phrase.