Inter-connection implies a connection between two or more entities. Its antonym, therefore, would be disconnection or isolation. Disconnection suggests a lack of connection or interruption of communication between two entities. On the other hand, isolation refers to the state of being separated from others or being alone. Other possible antonyms for inter-connection may include separation, segregation, detachment or dissociation. These words suggest a lack of link or mutual interaction between two or more entities. Opposite of inter-connection are important to understand and use appropriately, especially while expressing contrasting ideas or emphasizing the significance of relationships or communication.