Ion semiconductor sequencing is a technique that has emerged as a popular alternative to conventional Sanger sequencing. This sequencing method introduces several synonyms that are often interchanged and used interchangeably. Some of these synonyms include next-generation sequencing, rapid genome sequencing, and high-throughput sequencing. Similarly, some researchers refer to it as semiconductor sequencing, which means ion semiconductor sequencing works by detecting positive ions emitted as each base on a DNA strand is incorporated into a new DNA strand. Another commonly used term for this sequencing method is Ion Torrent sequencing, which is a technique that employs semiconductor technology to determine the sequence of nucleotides in DNA samples. In summary, all these are synonyms for ion semiconductor sequencing that are used differently by researchers in the scientific community.