The word "irritant" refers to something that causes annoyance or frustration, often related to physical or mental discomfort. Synonyms for this word include agitator, annoyance, nuisance, bother, pest, and hassle. Another synonym for this word is provocation, which implies a deliberate attempt to provoke anger or annoyance. Other synonyms may include vexation, exasperation, and frustration. Some related words in this context may include irritability, intolerance, and sensitivity. It is important to be mindful of one's own reactions to potential irritants and seek ways to manage or avoid them when possible.