Juvenile Amaurotic Idiocy, also known as Tay-Sachs Disease, is a rare and fatal genetic disorder that affects the nervous system. There are a few different synonyms for this condition, including GM2 gangliosidosis, hexosaminidase deficiency, and Tay-Sachs. All of these terms refer to the same condition, which leads to a progressive deterioration of the brain and nervous system. Symptoms of the disease typically start appearing within the first few months of life, and most patients do not survive beyond early childhood. Treatments and therapies for Tay-Sachs are currently limited, and research is ongoing to find a cure for this devastating condition.