The phrase "knuckled down to" means to concentrate and focus on a task or goal. Its opposite would be to slack off, procrastinate or be unfocused. Synonyms for "knuckled down to" are "got serious about," "took on," or "devoted oneself to." Antonyms might include "gave up," "lost interest," "ignored" or "distractions." It's important to stay motivated and dedicated to one's goals, to succeed and accomplish things in life. So, when you find yourself struggling to stay focused, remind yourself to "knuckle down to" the task at hand, and avoid its antonyms by pushing through, working hard, and staying focused.