The word "knuckled with" refers to being burdened or weighed down by something. Its antonyms would include "unencumbered," "light," "free," "unburdened," "unloaded," "unhindered," and "unhampered". These words signify a state of release from any responsibility, obligation or worry. The opposite of feeling knuckled with could indicate being carefree, relaxed, and able to move forward without hindrances. These antonyms offer a sense of ease and freedom, as opposed to feeling burdened or constrained. It's important to acknowledge and utilize these antonyms in our lives as they can help us feel more liberated and empowered.