"Leads a merry chase" is an idiom used to describe a situation where someone is pursuing or chasing after something in a playful and enjoyable manner. The antonyms for this phrase, therefore, can be words that convey seriousness, intensity, and lack of enjoyment. Some antonyms for "leads a merry chase" could be "pursues relentlessly," "chases doggedly," "follows with determination," or "tracks with persistence." These antonyms imply a serious, focused pursuit of an objective, with little to no room for fun or playfulness. While the phrase "leads a merry chase" may imply a lighthearted and enjoyable activity, its antonyms convey a sense of seriousness and solemnity.