The opposite of loosened up can be tightened, constricted, or restrained. When we feel uptight or wound up, we may need to find ways to relax and release tension. One way to do this is through mindfulness practices like meditation, deep breathing, or stretching. Other antonyms for loosened up might include rigid, inflexible, or tense. These words suggest a lack of mobility, adaptability, or spontaneity. Whether we are trying to unwind after a long day or overcome a challenging situation, the opposite of loosened up reminds us to stay patient, focused, and open to new possibilities.