There are numerous words that can be used as synonyms for the expression "loses one's reason." The most commonly used synonyms are "goes crazy," "loses one's mind," "loses one's sanity," "loses one's wits," and "loses one's marbles". Other synonyms can be "becomes unhinged," "loses control," "becomes unbalanced," and "loses touch." All of these expressions refer to the same thing; a person who experiences a mental breakdown or becomes unable to think or act rationally due to stress, pressure, or a traumatic experience. Using synonyms for "loses one's reason" helps to diversify your vocabulary and make your writing or speech more engaging and interesting.