Losing one's marbles is a colloquial expression that means losing one's mental faculties or sanity. However, there are many synonyms that can be used to describe the same thing. Some common ones include losing one's mind, going insane, losing one's grip, going bonkers, flipping out, cracking up, and becoming unhinged. Other more colorful synonyms include going off the deep end, becoming batty, losing one's noodle, going bananas, and going loony. While the expression "losing one's marbles" may be a fun and lighthearted way to describe a serious mental health issue, it's important to remember to use appropriate language and show empathy when discussing mental health concerns.