Losing one's wits is a phrase commonly used to describe a state of confusion or disorientation. There are many other words and phrases that can be used to convey a similar sentiment. Some examples include going bonkers, becoming unhinged, losing one's mind, losing one's marbles, going crazy, becoming deranged, flipping out, going insane, and going off the rails. Each of these phrases connotes a level of mental instability or emotional distress, often accompanied by irrational behavior or a lack of control. Whether used in a humorous or serious context, these synonyms allow us to express the feeling of losing one's bearings in a variety of ways.