The phrase "main thing" can be substituted with a wide range of synonyms. Some of the most common options include "primary focus," "crux of the matter," "key element," "primary objective," "essential element," "fundamental principle," and "central point." Other possible synonyms may include "core principle," "vital element," "primary concern," "key issue," or "central focus." Ultimately, the most appropriate synonym to use will depend on the context of the sentence and the intended meaning of the phrase. Whatever the case, there are plenty of alternatives to choose from that can help add variety and nuance to one's writing or speech.