The phrase "make little of" refers to the act of downplaying or belittling something or someone. There are several synonyms that can be used interchangeably with this expression, including trivialize, minimize, discount, ignore, overlook, and undervalue. When we use these synonyms, we are expressing a lack of importance or significance towards the subject in question. However, it is essential to remember that making little of someone or something can have adverse effects on people's self-esteem, perception, and overall well-being. Therefore, it is vital to choose our words carefully and avoid using language that may hurt others intentionally or unintentionally.