The word "makes handsome" refers to the act of enhancing someone's physical appearance. Its antonyms are words that convey the opposite meaning. These may include words like uglify, disfigure, deform, mar, deface, ruin, and spoil. If someone is described as being "uglified," then it means that their appearance has been made worse. Similarly, the words disfigure, deform, mar, deface, ruin, and spoil also emphasize the negative impact of an action on a person's appearance. Antonyms for "makes handsome" are useful when describing a negative change to someone's appearance or when discussing an alteration in someone's looks that is not desirable.