The phrase "makes tough" refers to the act of making something difficult or challenging. There are several antonyms, or opposites, for this phrase which include ease, facilitate, simplify, streamline, and smooth. For instance, if someone wants to make a process easier, they can facilitate it by removing any unnecessary steps or providing helpful resources. Alternatively, if someone wants to simplify a task, they may streamline it by breaking it down into more manageable components. Ultimately, there are many ways to counteract the effects of things that make tough, and using these antonyms can help to achieve a successful outcome.