McArdle Disease, also known as Glycogen Storage Disease Type V, is a rare genetic disorder characterized by the absence of an enzyme called myophosphorylase. This condition primarily affects skeletal muscles, leading to muscle weakness and fatigue, especially during exercise. Due to its medical significance, McArdle Disease is also referred to by various synonymous terms, such as Glycogenosis Type V, McArdle's Syndrome, and Adult Glycogen Storage Disease. These different names all encompass the same condition, allowing physicians, researchers, and patients to communicate effectively regarding the diagnosis, treatment, and management of this disorder. Awareness of these synonyms ensures a better understanding, improved interactions, and effective medical interventions concerning McArdle Disease.