Meckel syndrome, also known as Gruber syndrome, is a rare genetic disorder that affects multiple organ systems in the body. The syndrome is characterized by abnormalities in the brain, kidneys, liver, and skeletal system. Other synonyms for this syndrome include Meckel-Gruber syndrome, dysencephalia splanchnocystica, and Meckel syndrome type I. The syndrome is inherited in an autosomal recessive manner, meaning that an affected individual must inherit two copies of the mutated gene - one from each parent. Currently, there is no cure for Meckel syndrome, and treatment options are limited to managing symptoms and providing supportive care to affected individuals. In severe cases, infants born with this condition may not survive beyond infancy.