Minamata disease, also known as Chisso-Minamata disease, is a neurological syndrome caused by severe mercury poisoning. The symptoms of this disease include numbness of the fingers and toes, muscle weakness, impaired speech, vision, and hearing, and in severe cases, paralysis, coma, and death. Alternative names for the disease include organic mercury poisoning, methylmercury poisoning, and Minamata Bay disease. Methylmercury poisoning occurs when mercury accumulates in the food chain, especially in fish and shellfish contaminated with industrial waste. The disease was first identified in 1956 in Minamata, a Japanese fishing village, where industrial pollution from a local chemical plant poisoned and killed thousands of people.