Monoblastic leukemia is a rare but serious form of leukemia, also known as AML-M5. The disease affects the myeloid blasts, which are immature white blood cells in the bone marrow. As the name suggests, monoblastic leukemia originates from a single type of blast cells which grow uncontrollably and hinder the growth of normal cells. Some synonyms for this disease may include acute myeloid leukemia (AML), acute leukemia, and acute leukemia of ambiguous lineage. Treatment for monoblastic leukemia typically involves chemotherapy and bone marrow transplantation, and the prognosis varies depending on several factors. It is crucial to consult with a specialist for proper diagnosis and management of the condition.