Monoclonal gammopathy of renal significance is a condition in which an abnormal protein (monoclonal protein) is produced by a single clone of plasma cells in the bone marrow. This can cause damage to the kidneys and impair their function. Some common synonyms for monoclonal gammopathy of renal significance include monoclonal protein deposition disease, light chain deposition disease, and monoclonal immunoglobulin deposition disease. These terms are often used interchangeably and refer to the same underlying pathology. While the condition is rare, it is important to recognize its symptoms and get prompt medical attention to prevent further damage to the kidneys.