When looking for antonyms for the phrase "most afflicting," we can consider words that represent positive, uplifting, and joyful experiences. These could include phrases such as "most enjoyable," "most pleasant," or "most delightful." Words like "most comforting," "most soothing," or "most reassuring" can also be antonyms, as they represent the opposite of something that causes pain or distress. In contrast to "most afflicting," other phrases that may be seen as antonyms include "most satisfying," "most fulfilling," and "most rewarding." All of these words and phrases represent the opposite of affliction, highlighting the different types of experiences people can have in life.