Most agonized refers to extreme emotional distress, pain, or torment. Its antonyms are words that convey the opposite meaning, such as serene, content, and peaceful. Serene denotes a state of calmness or tranquility, free from disturbance. Content means satisfied or fulfilled, entirely at ease with one's circumstances. Peaceful refers to a state of harmony or quietness, absent of strife, turmoil, or stress. Other antonyms for most agonized may include happy, joyful, elated, delighted, and blissful. These antonyms convey a sense of optimism and positivity, countering the negative emotions associated with the word most agonized.