The phrase "most apprised" means having the most knowledge or understanding of something. The antonyms of this phrase are "least informed," "least aware," or "least knowledgeable." The opposite of being apprised is to be uninformed, ignorant, or oblivious. If someone is the least apprised of a situation, they may not have all the facts or details necessary to make an informed decision. It is important to seek out accurate information and strive to be well-informed, rather than relying on assumptions or hearsay. Increasing one's awareness and understanding can lead to better outcomes and more effective decision-making in various situations.