The word "most blighted" refers to something that is severely damaged or ruined. The antonyms for this word would be terms that reflect the opposite, such as "thriving," "prosperous," "flourishing," and "successful." These antonyms imply that something is vibrant, lively, and growing, rather than damaged or destroyed. For example, a city can be considered "flourishing" if its businesses are booming, its residents are happy, and its infrastructure is strong. Alternatively, the opposite of "most blighted" can also be "undamaged," "intact," "whole," or "undisturbed." These antonyms would suggest that something is free from damage or harm and retains its original state.