When dealing with antonyms, one must first understand what the word "most bottom-line" means. This term is commonly used in business and finance to refer to the most crucial or essential aspect of a decision or action. Its antonyms, on the other hand, would describe the least important or peripheral aspects. Some suitable antonyms for "most bottom-line" could include inconsequential, unimportant, secondary or peripheral. In contrast, synonyms for the term could be critical, vital, essential, or significant. Knowing the antonyms and synonyms for terms frequently used in specific industries or contexts can be very useful for effective communication and decision-making.