The antonyms for the word "most comforted" are plagued, disturbed, uneasy, perturbed, restless, upset, distressed, and troubled. These words convey a sense of unease, discomfort, and unrest, all of which are the opposite of feeling comforted. Whereas being comforted brings a feeling of peace, calm, and security, being plagued or perturbed denotes a state of agitation and uncertainty. Being uneasy or restless means one is unable to relax or feel at ease. Therefore, the antonyms for "most comforted" describe a range of negative emotions that have the opposite effect of providing comfort.