Most destructible means that something is highly prone to damage or destruction. Its antonym, therefore, would be "least destructible," meaning that something is difficult to damage or destroy. Other antonyms for most destructible include "durable," "strong," "resilient," and "indestructible." These words refer to materials, structures, or objects that can withstand wear and tear, weather conditions or even heavy usage, and last for a long time. Using materials that are least destructible can save time, money, and reduce the environmental impact of frequent replacements.