The antonyms of the word "most desponding" are optimistic, hopeful, cheerful, and bright. When one is optimistic, they have a positive attitude towards life, and they believe that good things will happen. Similarly, hopeful individuals have a sense of possibility, and they remain confident that their dreams will come true. Conversely, individuals who are cheerful are happy, positive, and lively. They naturally have a good mood and a positive outlook on life. Lastly, bright individuals have a sharp mind, and they approach life with intelligence, wit, and creativity. In all, these antonyms of the word "most desponding" reflect different attitudes, behaviors, and mindsets. Each one represents a different way of seeing the world and approaching life.