Most emptyhanded means having the least amount of something or receiving the least desired results. Antonyms for this phrase can include the terms most successful, most fruitful, most productive, most profitable, most satisfying, and most accomplished. These words indicate a positive outcome, whereas most emptyhanded implies a negative one. For example, if someone goes into a sales meeting with no sales or leads, they would come out feeling most emptyhanded. However, if they went in and landed a big sale or multiple leads, they would feel most successful or accomplished. The antonyms for most emptyhanded can help describe a more positive outcome.