Down-and-out is a term used to describe someone who is in a difficult or desperate financial and social situation. Antonyms for this term would be words that describe the opposite, such as wealthy, prosperous, successful, thriving, and fortunate. Successful describes someone who has achieved their goals and is doing well in their field or career. Wealthy describes someone who has an abundance of money, resources, and possessions. Prosperous describes someone who is doing well financially and has a stable and secure future. Thriving describes someone who is growing and thriving in their personal and professional life. Fortunate describes someone who has good luck, opportunities, and positive circumstances on their side.