Most estranged means to be the farthest apart or distant from someone or something. The opposite of this would be the word "closest" or "nearest." Both of these words suggest a strong sense of closeness and familiarity, qualities that are the opposite of estrangement. Other antonyms for most estranged may include words such as "connected," "united," or "intimate." These words describe relationships that are close and harmonious, with a sense of mutual respect and understanding. When we are closest to someone, we feel a sense of trust and comfort that is the opposite of the feelings of separation and isolation that often accompany estrangement.