Antonyms are words that are opposite in meaning. For the word "most gladdened," which means feeling extreme joy or happiness, the antonyms can include despairing, gloomy, sad, heartbroken, dejected, and miserable. If someone is not pleased or delighted, they might be unhappy or upset, which are also antonyms for the word "gladdened." Other antonyms for "most gladdened" could be disappointed, downcast, discouraged, disheartened, and dispirited. It is essential to have a clear understanding of antonyms as it helps to improve vocabulary, language skills, and communication in day-to-day life.