Guffaw is a term used to describe a loud and hearty burst of laughter. There are many synonyms for the word 'most guffaw' that can be used to describe such laughter. Some of the common synonyms for guffaw include chuckle, giggle, snigger, and chortle. Each of these words is used to describe a different type of laughter, from a gentle and quiet chuckle to a loud and boisterous guffaw. Other synonyms for guffaw include roar, belly laugh, cackle, and howl. These words are all used to describe loud and infectious laughter that cannot be contained. Whatever word you use, there's no denying the joy and happiness that comes from a good laugh.