The term "most guiding" implies being the most significant, influential, or leading. The antonyms for this phrase could be "least guiding," indicating something that is not very influential or important. Other antonyms could be "uninfluential," "unimportant," or "insignificant." These words describe the opposite of the guiding force that "most guiding" represents. Additionally, antonyms could include "misguiding," which implies the opposite of leading, or "confusing." Overall, the antonyms for "most guiding" depict ideas that are less important or ineffective in leading or directing someone towards a particular goal or objective.