The term "most hampered" describes a state of being hindered, restricted or limited to the highest degree. Antonyms for this phrase could include "uninhibited", "unrestricted", "unencumbered", "unbridled", "unfettered", "unimpeded", "free", "facile", "effortless", "unhindered", and "unburdened". These antonyms would imply a state of freedom, ease, and flexibility, unencumbered by any limitations, hindrances, or obstacles. To move away from being "most hampered" towards these antonyms would require overcoming whatever is causing the present hindrances or limitations, embracing opportunities for growth and development, and pursuing one's goals with tenacity, courage, and creativity.