The antonyms for the word "most heeded" are disregarded, ignored, neglected, overlooked, and slighted. These words indicate a lack of attention, consideration, or importance given to a particular matter or person. When someone or something is disregarded, it means that they are not taken seriously or given the appropriate level of attention. The same can be said for being ignored, neglected, overlooked, or slighted. These antonyms emphasize the opposite of being heeded or listened to, highlighting the importance of paying attention and giving due respect to matters of significance.