The antonyms for the word "most high-principled" are "unscrupulous," "dishonest," "immoral," "sneaky," and "deceitful." These words describe individuals who lack integrity, principles, and moral standards. They may manipulate and deceive others for their personal gain and disregard the importance of honesty and fairness. While high-principled individuals prioritize ethical behavior, those who possess the opposite characteristics prioritize their own desires and goals, often at the expense of others. Therefore, it is essential to surround oneself with individuals who embody high-principled qualities and avoid those who display the opposite traits.