When discussing infectious diseases, it's essential to have a variety of words to describe the level of infection. Synonyms for "most infected" are numerous and include terms such as "most affected," "hardest-hit," "worst affected," "most impacted," and "most afflicted." Each of these words conveys a sense of severity when discussing the number of cases of an illness. Additionally, understanding these synonyms can help convey accurate information when speaking about a particular disease outbreak or pandemic. As such, having a wide range of descriptive words is essential when communicating about infectious diseases and their impact on communities.